General Information

  • ID:  hor003025
  • Uniprot ID:  P34966
  • Protein name:  Neuromedin U
  • Gene name:  NMU
  • Organism:  Cavia porcellus (Guinea pig)
  • Family:  NmU family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Cavia (genus), Caviidae (family), Hystricomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0006940 regulation of smooth muscle contraction; GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GYFLFRPRN
  • Length:  9(1-9)
  • Propeptide:  GYFLFRPRN
  • Signal peptide:  NA
  • Modification:  T9 Asparagine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  smooth muscle contractile activity
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-B3H5A9-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-B3H5A9-F1.pdbhor003025_AF2.pdbhor003025_ESM.pdb

Physical Information

Mass: 131221 Formula: C56H80N16O12
Absent amino acids: ACDEHIKMQSTVW Common amino acids: FR
pI: 11.15 Basic residues: 2
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: -71.11 Boman Index: -2480
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 43.33
Instability Index: 2618.89 Extinction Coefficient cystines: 1490
Absorbance 280nm: 186.25

Literature

  • PubMed ID:  2381877
  • Title:  Isolation and Microsequence Analysis of a Novel Form of Neuromedin U From Guinea Pig Small Intestine